Symbol
Name
ID

Pkd2
polycystin 2, transient receptor potential cation channel
MGI:1099818

Phenotype annotations related to renal/urinary system

Darker colors indicate more annotations

Human Phenotypes

Abnormal urinary electrolyte concentration

Hematuria

Albuminuria

Enlarged kidney

Calcium oxalate nephrolithiasis

Uric acid nephrolithiasis

Renal cyst

Multiple renal cysts

Polycystic kidney dysplasia

Decreased glomerular filtration rate

Pyelonephritis

Renal insufficiency

Chronic kidney disease

Stage 5 chronic kidney disease

Recurrent urinary tract infections

Disease(s) Associated with PKD2

autosomal dominant polycystic kidney disease

polycystic kidney disease 2

Mouse Phenotypes

increased kidney apoptosis

increased kidney cell proliferation

kidney cyst

kidney cortex cyst

kidney medulla cyst

polycystic kidney

enlarged kidney

increased kidney weight

abnormal kidney morphology

abnormal papillary duct morphology

dilated kidney collecting duct

increased glomerular capsule space

dilated proximal convoluted tubule

dilated renal tubule

kidney failure

Availability

Mouse Genotype

Pkd2^m1Btlr/Pkd2^m1Btlr

Pkd2^tm1Dwo/Pkd2^tm1Dwo

Pkd2^tm1Gwu/Pkd2^tm1Gwu

Pkd2^tm1Som/Pkd2^tm1Som

Pkd2^tm2Som/Pkd2^tm2Som

Pkd2^tm1Som/Pkd2⁺

Pkd2^tm1Som/Pkd2^tm2Som

Pkd2^tm2Som/Pkd2⁺

Pkd2^tm1.1Gwu/Pkd2^tm1.1Gwu
Tg(Vil1-cre)997Gum/0 (conditional)

Pkd2^tm3Som/Pkd2^tm3Som
Tg(Pkhd1-cre)1Igr/? (conditional)

Pkd2^tm3Som/Pkd2^tm3Som
Tg(Pkhd1-cre)1Igr/0 (conditional)

Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt
Meox2^tm1(cre)Sor/Meox2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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